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CCR1 inhibitor 19e

CAS No. 1220026-26-5

CCR1 inhibitor 19e( —— )

Catalog No. M10832 CAS No. 1220026-26-5

CCR1 inhibitor 19e is a novel potent, selective CCR1 antagonist with IC50 of 6.8 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    CCR1 inhibitor 19e
  • Note
    Research use only, not for human use.
  • Brief Description
    CCR1 inhibitor 19e is a novel potent, selective CCR1 antagonist with IC50 of 6.8 nM.
  • Description
    CCR1 inhibitor 19e is a novel potent, selective CCR1 antagonist with IC50 of 6.8 nM, inhibits CCR1chemotaxis in THP-1 cells with IC50 of 28 nM.
  • In Vitro
    CCR1 antagonist 9 (Compound 19e) blocks the CCR1 chemotaxis of THP-1 cells with an IC50 of 28 nM. CCR1 antagonist 9 also blocks hERG with an IC50 of 30 μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Chemokine Receptor
  • Recptor
    Chemokine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1220026-26-5
  • Formula Weight
    425.438
  • Molecular Formula
    C20H16FN5O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 83.33 mg/mL (195.87 mM)
  • SMILES
    CS(=O)(=O)C1=NC=CC(=C1)CNC(=O)C2=CN=CC3=C2C=NN3C4=CC=C(C=C4)F
  • Chemical Name
    1-(4-fluorophenyl)-N-((2-(methylsulfonyl)pyridin-4-yl)methyl)-1H-pyrazolo[3,4-c]pyridine-4-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Harcken C, et al. Bioorg Med Chem Lett. 2018 Dec 13. pii: S0960-894X(18)30958-2. doi: 10.1016/j.bmcl.2018.12.024.
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